教师介绍

郑晨光

来源:更新时间:2023-03-02

姓 名 郑晨光
职 称 教授
所在系别 生物医学工程系
所属课题组 天津大学神经工程与康复实验室
联系电话 022-83622122
电子邮件 cgzheng@tju.edu.cn
办公地址 精仪学院第17教学楼515室
主讲课程 《医学概率统计与实验设计》,智能医学工程本科专业基础课
《Medical Statistics》,研究生核心课(全英文)
《医学统计学》,研究生选修课
《Principles and Advanced Technology in Neuroscience》,
研究生选修课(全英文)
导师类型 博导
通讯地址 天津市南开区卫津路92号
邮政编码 300072

个人经历或学术经历
  1. 2004-2008,南开大学数学科学学院数学与应用数学专业,本科;
  2. 2008-2013,南开大学生命科学学院生物信息学专业,博士;
  3. 2013-2018,美国德州大学奥斯汀分校神经科学系,博士后研究员;
  4. 2018至今,天津大学精仪学院生物医学工程系,教授。

研究方向

  课题组聚焦于高级认知功能的神经解码与调控研究,具体为:

  1. 1. 空间导航、学习记忆、社交、奖赏等功能的神经集群编码模式与神经节律(theta和gamma)的调节机制研究;
  2. 2. 决策功能在线解码与闭环调控的神经接口研究;
  3. 3. 神经退行性疾病(如阿尔茨海默症)和精神类疾病(如抑郁症)的神经编码损伤机制及物理调控研究。

  主要技术:多通道清醒在体电生理、光遗传、超微显微成像、深部电刺激、超声调控、神经网络信号处理、统计学习算法等。

  本课题组常年招收生物医学工程、生物学、数学统计、自动化及信息类相关专业的硕/博士研究生;招聘博士后,有神经科学、人工智能、生物学、或者医学背景的优先,掌握电生理和钙成像技术、信号处理者优先,动手能力和学习能力较好或者有其他学术特长的可以放宽专业和技术要求。请有意者提前通过邮件咨询。

科研项目、成果和专利

在研:

  1. 1. 国家自然科学基金面上项目,82271218,神经集群序列性表征在阿尔茨海默病空间记忆损伤中的作用及其靶向干预策略研究,2023/01-2026/12,52万元
  2. 2. 科技创新2030“脑科学与类脑研究”专项,认知地图的神经机制,2022/08-2027/7,333万元
  3. 3. 科技部重点研发项目子课题,2020YFC2004302,多维度信息融合在线评价及自适应康复训练技术研究,2020/07-2023/06,113万元
  4. 4. 临港实验室-中国航天员中心人因工程国家级重点实验室“求索太空脑计划”项目,LG-TKN-202204-01,2022/11-2025/10,50万元
  5. 5. 天津市重点项目,20JCZDJC00540,微服务架构脑系科专病数据库的构建和临床预测模型研究,2020/04-2023/03,20万元

结题:

  1. 1. 国家自然科学基金面上项目,81870847,阿尔茨海默症大鼠海马—前额叶Gamma节律在认知障碍中的神经损伤机制与调控研究,2019/01-2022/12,56万元
  2. 2. 国家自然科学基金青年项目,31800889,目标导向空间记忆中海马Gamma节律实现精准序列编码的神经机制研究,2019/01-2021/12,26万元
  3. 3. 天津市自然科学基金面上项目,AD大鼠空间记忆损伤中gamma振荡编码模型与时空靶向电刺激调控研究,2019/04-2022/03,10万元

论文、专著

神经解码:

  1. 1.Zheng C*, Hwaun E, Loza CA, Colgin LL* (2021) Hippocampal place cell sequences differ during correct and error trials in a spatial memory task. Nature Communications. 12(1): 3373.
  2. 2.Zhu N1, Zhang Y1, Xiao X, Wang Y, Yang J, Colgin LL, Zheng C* (2022) Hippocampal oscillatory dynamics in freely behaving rats during exploration of social and non-social stimuli. Cognitive Neurodynamics.
  3. 3.Wang X1, Wang Y1, Wang L, Yang J*, Zheng C* (2022) Impairment of Neural Rhythms in the Hippocampus in Different Behavioral Phases Induced by Amyloid-β Accumulation. 9th International Conference on Biomedical and Bioinformatics Engineering (ICBBE). Accepted.
  4. 4.Meng S, Wang Y, Wang L, Yang J*, Zheng C* (2022) Reward Coding of Hippocampal Neurons in Goal-directed Spatial Memory. 9th International Conference on Biomedical and Bioinformatics Engineering (ICBBE). Accepted.
  5. 5.Liu Z, Wang Y, Yang J, Wang L*, Zheng C* (2022) Stable Firing Pattern of Excitatory Neurons in the Prefrontal Cortex of Rats during Social Behaviors. 9th International Conference on Biomedical and Bioinformatics Engineering (ICBBE). Accepted.
  6. 6.Luo X, Zhu N, Wang N, Wang L, Yang J, Zheng C* (2022) Predictive Coding of Hippocampal Place Cell Ensembles during Early Phase of Spatial Decision-making. 9th International Conference on Biomedical and Bioinformatics Engineering (ICBBE). Accepted.
  7. 7.Zheng L1, Zhu N1, Wang Y, Wang X, Wang L*, Zheng C* (2022) Development of Hippocampal Replay with Learning in Spatial Memory of Precise Goal Locations. 9th International Conference on Biomedical and Bioinformatics Engineering (ICBBE). Accepted.
  8. 8.Zheng L1, Wang L1, Yang J, Zheng C* (2022) Impaired cognitive map in Alzheimer's Disease transgenic animals: from neurons to network. Acta Physiologica Sinica. Accepted.
  9. 9.Wang X, Wang Y, Yang J, Zheng C* (2021) Memory-dependent Neural Rhythms Coupling in Hippocampal-prefrontal Cortex Network. Progress in Biochemistry and Biophysics. 48 (8): 907-921
  10. 10.Bai Y, Yang J, Zheng C* (2020) Gamma Rhythms: A Potential Diagnostic Target for Cognitive Disorders. Progress in Biochemistry and Biophysics. 47 (6): 523
  11. 11.Zhang Y, Zhu N, Yang J, Zheng C* (2020) Progress in the encoding characteristics and mechanisms of hippocampal neural assemble sequences in spatial memory. Acta Physiologica Sinica. 72(6): 793-803.
  12. 12.Zheng C*, Colgin LL* (2017) A neuronal mechanism for recall of bad events. Nature Neuroscience. 20(4): 501-503.
  13. 13.Zheng C*, Bieri KW, Hsiao Y, Colgin LL* (2016) Spatial sequence coding differs during slow and fast gamma rhythms in the hippocampus. Neuron. 89(2): 398-408.
  14. 14.Alexander GM, Farris S, Pirone JR, Zheng C, Colgin LL, Dudek SM* (2016) Social and novel contexts modify hippocampal CA2 representations of space. Nature Communications. 7: 10300.
  15. 15.Zheng C*, Bieri KW, Hwaun E, Colgin LL* (2016) Fast gamma rhythms in the hippocampus promote encoding of novel object-place pairings. eNeuro. 3(2).
  16. 16.Hsiao Y, Zheng C and Colgin LL* (2016) Slow gamma rhythms in CA3 are entrained by slow gamma activity in the dentate gyrus. Journal of Neurophysiology. 116(6): 2594-2603.

神经调控:

  1. 1. Liang R1, Wang L1, Li X, Liu X, Chang H, Xu Q, Wang Y, Xu D, Liu D, Yang J*, Zheng C*, Ming D*,Repetitive transcranial magnetic stimulation rescues simulated space complex environment–induced emotional and social impairments by enhancing neuronal excitability in the medial prefrontal cortex. Cerebral Cortex. Online publication.
  2. 2.Wang Y1, Bai Y1, Xiao X, Wang L, Wei G, Guo M, Song X, Tian Y, Ming D, Yang J*, Zheng C* (2022) Low-intensity focused ultrasound stimulation reverses social avoidance behavior in mice experiencing social defeat stress. Cerebral Cortex. 32(24): 5580-5596.
  3. 3.Wang F1, Wang Q1, Wang L, Ren J, Song X, Tian Y, Zheng C, Yang J*, Ming D* (2022) Low-Intensity Focused Ultrasound Stimulation Ameliorates Working Memory Dysfunctions in Vascular Dementia Rats via Improving Neuronal Environment. Frontiers in Aging Neuroscience. 14: 814560.
  4. 4.Wang L, Yang J, Xiao X, Zheng C and Ming D* (2021) VEGF Modulates the Neural Dynamics of Hippocampal Subregions in Chronic Global Cerebral Ischemia Rats. Neuromolecular Med. 23(3): 416-427.
  5. 5.Yang J, Liang R, Wang L, Zheng C, Xiao X and Ming D* (2021) Repetitive Transcranial Magnetic Stimulation (rTMS) Improves the Gait Disorders of Rats Under Simulated Microgravity Conditions Associated With the Regulation of Motor Cortex. Front Physiol. 12: 587515.
  6. 6.Li Y, Xiao X, Wang L, Wang Q, Liang R, Zheng C, Yang J*, Ming D* (2021) Comparison effects of chronic sleep deprivation on juvenile and young adult mice. J Sleep Res. e13399.
  7. 7.Yang J, Wang L, Wang F, Tang X, Zhou P, Liang R, Zheng C*, Ming D* (2019) Low-Frequency Pulsed Magnetic Field Improves Depression-Like Behaviors and Cognitive Impairments in Depressive Rats Mainly via Modulating Synaptic Function. Frontiers in Neuroscience. 13: 820

神经节律:

  1. 1.Xu X1, Zheng C1, An L, Wang R, Zhang T* (2016) Effects of dopamine and serotonin systems on modulating neural oscillations in hippocampus-prefrontal cortex pathway in rats. Brain Topography. 29(4): 539-551. (1共同第一作者).
  2. 2.Li Q1, Zheng C1, Cheng N, Wang Y, Yin T, Zhang T* (2016) Two generalized algorithms measuring phase–amplitude cross-frequency coupling in neuronal oscillations network. Cognitive Neurodynamics. 10(3):235-243. (1共同第一作者).
  3. 3.Zheng C, Colgin LL* (2015) Beta and gamma rhythms go with the flow. Neuron. 85(2): 236-237.
  4. 4.Zheng C*, Bieri KW, Trettel SG, Colgin LL* (2015) The relationship between gamma frequency and running speed differs for slow and fast gamma rhythms in freely behaving rats. Hippocampus. 25(8): 924-938.
  5. 5.Zheng C, Zhang T* (2015) Synaptic plasticity-related neural oscillations on hippocampus-prefrontal cortex pathway in depression. Neuroscience. 292: 170-180
  6. 6.Zheng C, Zhang T* (2013) Alteration of phase-phase coupling between theta and gamma rhythms in a depression-model of rats. Cognitive Neurodynamics. 7(2): 167-172.
  7. 7.Xu X, Zheng C, Zhang T* (2013) Reduction in LFP cross-frequency coupling between theta and gamma rhythms associated with impaired STP and LTP in a rat model of brain ischemia. Frontiers in Computational Neuroscience. 7: 27.
  8. 8.Zheng C, Quan M, Zhang T* (2012) Decreased thalamo-cortical connectivity by alteration of neural information flow in theta oscillation in depression-model rats. Journal of Computational Neuroscience. 33(3): 547-558.
  9. 9.Zhang M1, Zheng C1, Quan M, An L, Yang Z, Zhang T* (2011) Directional indicator on neural oscillations as a measure of synaptic plasticity in chronic unpredictable stress rats. Neurosignals. 19(4): 189-197. (1共同第一作者).
  10. 10.Zheng C, Quan M, Yang Z, Zhang T* (2011) Directionality index of neural information flow as a measure of synaptic plasticity in chronic unpredictable stress rats. Neuroscience Letters. 490(1): 52-56.
  11. 11.Quan M, Zheng C, Zhang N, Han D, Tian Y, Zhang T, Yang Z* (2011) Impairments of behavior, information flow between thalamus and cortex, and prefrontal cortical synaptic plasticity in an animal model of depression. Brain Research Bulletin. 85(3-4): 109-116.
  12. 12.Zheng C, Li Q, Wang Y, Zhang T* (2016) Theta phase time-delayed modulating low amplitude in hippocampal CA3-CA1 network. Advances in Cognitive Neurodynamics (V), Chapter 37: 259-265.
  13. 13.Zheng C, Zhang T* (2016) Role of DA and 5-HT in modulating neural oscillatory synchronization. Advances in Cognitive Neurodynamics (V), Chapter 37: 267-273.
  14. 14.Zheng C, Yang Z, Zhang T* (2015) Phase coupling between hippocampal CA1 and prefrontal cortex in a depression-model rats indicating impaired synaptic plasticity. Advances in Cognitive Neurodynamics (IV), Chapter 40: 283-288.

奖励、荣誉和学术兼职

本人获奖:

  1. 2020,天津市创新人才推进计划青年科技优秀人才(天津市科学技术局)
  2. 2020,中国生物技术创新大会最佳组织团队奖(科技部)
  3. 2020,第十七届中国青年女科学家天津市推荐候选人(天津市科学技术局)
  4. 2019,中国工程前沿杰出青年学者(中国工程院)
  5. 2019,天津大学本科生毕业设计优秀指导教师(天津大学)
  6. 2016,天津市高层次人才计划(天津市科学技术局)

指导学生获奖:

  1. 2019级博士王伊萌获得天津大学“优秀博士学位论文基金”资助
  2. 2019级硕士朱楠获得中国神经科学科学年会 Award for Excellent Poster奖
  3. 2019级硕士王雪玲获得天津大学优秀毕业生荣誉
  4. 2021级硕士郑丽获得2022年ICBBE国际会议Best Presentation Award
  5. 2022级博士王雪玲获得2022年ICBBE国际会议Best Presentation Award
  6. 2021级硕士郑丽获得天津大学三好学生荣誉称号

社会学术兼职:

  1. 《生物医学工程学杂志》编委
  2. 天津市脑科学与神经工程重点实验室,常务副主任
  3. 天津市急腹症器官损伤与中西医修复重点实验室学术委员会,委员
  4. 天津市中西医结合急腹症临床医学中心学术委员会,委员
  5. 脑科学权威期刊Current Opinion in Neurobiology, Cerebral Cortex, Neural Regeneration Research等的匿名审稿人

 

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